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约翰斯·霍普金斯大学：抗寄生虫药物可减缓小鼠身上的胰腺癌发展_我的网站

一 |     在发表于《Oncotarget》杂志的一项研究中，约翰斯·霍普金斯大学医学院神经外科和肿瘤学教授Gregory Riggins博士和他的团队使用两种不同的小鼠模型来确定抗寄生虫药物甲苯达唑可以减缓或阻止早期和晚期胰腺癌的生长和扩散。    London, Oct 12 (UNI) Refugee families in Syrian camps are begging for donations on TikTok while the company takes up to 70 per cent of the proceeds, a BBC investigation has found.

Children are livestreaming on the social media app for hours, pleading for digital gifts with a cash value.

The BBC saw streams earning up to $1,000 (£900) an hour, but found refugees received only a tiny fraction of that.

TikTok said it would take prompt action against "exploitative begging", the BBC report said.

The company said this type of content was not allowed on its platform, and it said its commission from digital gifts was significantly less than 70 per cent. But it declined to confirm the exact amount.

Earlier this year, TikTok users saw their feeds fill with livestreams of refugee families in Syrian camps, drawing support from some viewers and concerns about scams from others.

In the camps in north-west Syria, the BBC found that the trend was being facilitated by so-called "TikTok middlemen", who provided families with the phones and equipment to go live.

The middlemen said they worked with agencies affiliated to TikTok in China and the Middle East, who gave the families access to TikTok accounts. These agencies are part of TikTok's global strategy to recruit livestreamers and encourage users to spend more time on the app, the BBC said.

The gifts they're asking for are virtual, but they cost the viewers real money and can be withdrawn from the app as cash. Livestream viewers send the gifts - ranging from digital roses, costing a few cents, to virtual lions costing around $500 - to reward or tip creators for content.

For five months, the BBC followed 30 TikTok accounts broadcasting live from Syrian refugee camps and built a computer program to scrape information from them, showing that viewers were often donating digital gifts worth up to $1,000 an hour to each account.

Families in the camps said they were receiving only a tiny fraction of these sums, however, the BBC report said.

TikTok influencer and ex-professional rugby player Keith Mason donated $330 during one family's livestream and encouraged his nearly one million followers to do the same.

When told by the BBC that most of these funds were taken by the social media company, Mason said it was "ridiculous" and "unfair" to families in Syria.

"You've got to have some transparency. To me, that's very greedy. It's greed," he said.

TikTok's rules say you must have 1,000 followers before you can go live, you must not directly solicit for gifts and must "prevent the harm, endangerment or exploitation" of minors on the platform.

After the BBC contacted TikTok directly for comment, the company banned all of the accounts.

It said in a statement: "We are deeply concerned by the information and allegations brought to us by the BBC, and have taken prompt and rigorous action.

"This type of content is not allowed on our platform, and we are further strengthening our global policies around exploitative begging."

TikTok, the world's fastest-growing social media app, has made more than $6.2 billion in gross revenue from in-app spending since its launch in 2017, according to analytics company Sensor Tower.

UNI ING。

二 | “我们认为甲苯咪唑可能在所有阶段都有作用，”Riggins说。“它对早期发现的胰腺癌特别有效。”Riggins和他的团队将甲苯咪唑注射到经过基因工程改造后患上胰腺癌的小鼠身上。该团队测量了炎症和组织的变化，以及每个肿瘤的阶段、分级和转移状态。甲苯咪唑最初是通过切断寄生虫的营养供应来对抗蛔虫、钩虫和其他寄生虫感染，它能抑制微管蛋白的形成。Riggins解释说，微管蛋白既是细胞内部的微观“骨架”，也是“运输的高速公路”。

三 | 该药物进入寄生虫的肠道并破坏微管蛋白，使寄生虫饿死。该研究表明，甲苯咪唑可能在胰腺癌中发挥类似的作用，通过塌陷癌细胞的结构，同时还有其他机制，如减少炎症。Riggins说，他希望通过人体临床试验继续他的团队的研究：“我们主张将甲苯咪唑作为一种疗法用于那些在转移前被诊断出来的人，看看我们是否可以减缓或预防胰腺癌，”Riggins说。

四 | “对于那些更晚期的癌症患者，它可能是某些手术的替代方案。

五 | 甲苯咪唑作为初始治疗后的一种疗法可能有实用价值，以防止15%至20%接受手术的胰腺癌患者的肿瘤复发。它还可能增加其余80%至85%的晚期患者对标准化疗反应的持久性。

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